SIRT1 and neoplasm: Moreover, we identify here a correlation between VCP overexpression (highest expression) and induction of tumor associated proteins- NFκB, Nrf2 and SIRT1, and down regulation of tumor suppressor-p53 in NSCLC (H1299&H1944) cell lines (Figure 4a), suggesting the critical role of VCP-mediated proteasomal degradation in tumor cell proliferation and metastasis.