BCR and chronic myelogenous leukemia, BCR-ABL1 positive: CML cells producing BCR-Abl fusion protein, such as the K562 cell line, are important experimental models because they allow the assessment of multiple cellular and molecular events simultaneously, including various modes of cell death [15], [16], differentiation toward the erythroid/macrophage/megakaryocyte lineages [14], [16], [17], [18], [19], [20], and downegulation of BCR-Abl tyrosine kinase [21].