In this study we demonstrated that lapatinib induced myeloid leukemia cell death in CML K562, MEG-01, AML HL-60 and NB4 cells (Figs. 1A–1E) and showed much more toxicity than their normal counterpart human CD14+ monocytes, or mouse bone marrow cells (Fig. 1F). Here, CD14 is linked to acute myeloid leukemia.