It inhibited proapoptotic gene expression, induces anti-apoptotic gene expression [43], stimulates cytokine production [44], induces angiogenesis via VEGF, IL-8, PDGF [45], activation of various cell cycle genes [46], and enhances the expression of the multidrug resistance (MDR) protein and mediates chemoresistance of tumor cells [47]. This evidence concerns the gene CXCL8 and neoplasm.