Another target of ATF6α, BiP/GRP78 [24] also decreased in LDC-E and LDC-HF fed Mist1−/− mice (Figure 5A, C), supporting the findings that Mist1−/− mice had a reduction in ATF6 signaling as a result of ethanol or high-fat consumption. The gene discussed is BHLHA15; the disease is hydrops fetalis.