While trichrome histological staining did not reveal significant pancreatic fibrosis, 50% of ethanol fed Mist1−/− mice (6/12) also showed accumulation of adipocytes (compared to 0/23 of the WT mice and 0/11 LDC-HF fed Mist1−/− mice), often located adjacent to the site of inflammatory infiltrate (Figure 2Di) that were not observed in any other group. Here, BHLHA15 is linked to hydrops fetalis.