This suggests that while the activation of the UPR in response to LDC-E and LDC-HF diets was affected in Mist1−/− pancreatic tissue, only the inability to activate IRE1 signaling and trigger autophagy upon ethanol exposure correlates to focal inflammation observed in LDC-E fed Mist1−/− mice. The gene discussed is BHLHA15; the disease is hydrops fetalis.