Beside cancer, the development of several hypoxia-associated diseases including pulmonary artery hypertension, myocardial infarction and ischemic retinopathies has been linked to NHE-1 activity and cardiac-specific overexpression of a dominant negative form of RSK has been shown to reduce cardiac ischemia-reperfusion injury [66], [67], [68], [69], [70]. The gene discussed is RPS6KA1; the disease is pulmonary arterial hypertension.