The limited available data derived from cross-sectional studies in active tuberculosis disease and BCG-vaccinated unexposed controls indicate that interferon-γ (IFN-γ) T-cell responses to these antigens have high specificity (97.4%–100%) and low-to-moderate sensitivity (25.5%–53.1%) for active tuberculosis, after exclusion of cross-reactive peptides encoded in conserved motifs of Rv3873 [30], [35], [37]. The gene discussed is IFNG; the disease is tuberculosis.