NFKB1 and melanoma: Interestingly, niclosamide is an antihelmintic drug that was recently shown to inactivate the NF-κB pathway and to generate ROS in leukaemic stem cells, whereas terfenadine is an antihistamine that induces apoptosis in melanoma cells and causes massive hydrogen peroxide production in cultured cerebellar neurons (Diaz-Trelles et al, 2000; Jangi et al, 2008; Jin et al, 2010).