CHDH and congenital diaphragmatic hernia: On the other hand, compound knock-out mice for retinoic acid receptors (RAR) have phenotypes involving CDH and several of the associated malformations seen in this condition [107] whereas blockade of RAR with BMS493 induces CDH [108] and administration of BMS-189453, a RA antagonist, to pregnant mice reproduces the phenotype of CDH [109].