NRXN1 and schizophrenia: Addington and Rapoport [35] found that approximately 10% of childhood-onset schizophrenia patients in their cohort had cytogenetic abnormalities, including deletions of 22q11, atypical/mosaic 45,X and 47,XXX, recurrent duplications of 16p11.2 and MYT1L (mapped to 2p25.3), and deletion of NRXN1 (on 2p16.3), all of which have been reported in adult-onset schizophrenia patients.