Given the reports linking GNB3 825T to accelerated disease progression in Caucasians, the evidence demonstrating the role of G protein signaling in establishing HIV infection and the possibility of linkage disequilibrium between the CD4 and GNB3 SNPs, we sought to characterize the impact of the GNB3 SNP in two African cohorts: a high-risk commercial sex worker (CSW) cohort and a low-risk perinatal HIV transmission (PHT) cohort, both located in Nairobi, Kenya. Here, CD4 is linked to HIV infectious disease.