FA2H and leukodystrophy: Fatty acid 2-hydroxylase (FA2H) is involved in sphingolipid metabolism and mutations in this gene are known to cause leukodystrophy, whereas phosphatidylglycerophosphate synthase 1 (PGS1) is involved in glycerophospholipid metabolism, synthesizing phosphatidyl-glycerophosphate from CDP-diacylglycerol.