In clinical study, overexpression of Bmi-1 has been correlated with cancer susceptibility and poor prognosis in several human cancers, including non-small cell lung cancer (17), gastric carcinoma (18), hepatocellular carcinoma (19), acute myeloid leukemia (20), breast cancer (21), nasopharyngeal carcinoma (22), and bladder cancer (23). This evidence concerns the gene BMI1 and cancer.