In clinical study, overexpression of Bmi-1 has been correlated with cancer susceptibility and poor prognosis in several human cancers, including non-small cell lung cancer (17), gastric carcinoma (18), hepatocellular carcinoma (19), acute myeloid leukemia (20), breast cancer (21), nasopharyngeal carcinoma (22), and bladder cancer (23). The gene discussed is BMI1; the disease is breast cancer.