Another prominent gene of the signature observed in public databases that was not upregulated in the human xenografted cells is MMP11 (matrix metallopeptidase 11, aka stromelysin 3), in agreement with the hypothesis [13,18,19] that MMP11 is expressed in the adipocytes of the adjacent reactive stroma, indicating that the full version of the cancer mesenchymal transition signature may be stabilized by contextual microenvironmental signals when cancer cells encounter adipocytes triggering their dedifferentiation, apoptosis, or metabolism [13]. The gene discussed is MMP11; the disease is cancer.