To determine whether SNPs spanning ALOX5AP, LTA4H and LTB4R act as determinants of COPD susceptibility in smokers, we completed case-control association analyses comparing the smoking controls (n = 176) with the COPD subjects (n = 599), defined by post-bronchodilator spirometry (Table 2). This evidence concerns the gene LTA4H and chronic obstructive pulmonary disease.