At the 3rd day of infection, IFN-γ−/− mice presented a 10 fold increase in DENV-2 viral loads in spleen and DENV-2 titers in spleen of infected-IFN-γ−/− mice were above 1.5 log greater than in infected-WT mice in the 5th day of infection (Figure 1J). This evidence concerns the gene IFNG and infection.