On the contrary, cytokine-producing T cells (especially TNF-α and/or IFN-γ) were associated with DHF development in patients and these DHF associated, cytokine-producing T cells were shown to be negative for CD107a staining, suggesting that these lymphocyte populations represent mono-functional or oligo-functional T cells [51]. The gene discussed is LAMP1; the disease is Dengue hemorrhagic fever.