In addition, the ratio of TNF-α-producing to IFN-γ-producing T cells among peripheral blood mononuclear cells from dengue-vaccine recipients was shown to be greater after in vitro stimulation with antigen from heterologous dengue serotypes [39], suggesting that increased amounts of TNF-α alters response to infection and may result in more-severe disease manifestation. The gene discussed is IFNG; the disease is dengue disease.