Figure 6A and 6B show that fibroblasts undergo nuclear accumulation of IRF3 following infection with DENV-2. While in mock and uninfected cells, IRF3 distribution was predominantly cytoplasmic. By contrast, DENV infection of skin fibroblasts failed to induce IRF7 nuclear translocation at 24 or 48 h post-infection (Figure 6E), the location of the molecule was mainly cytoplasmic. At 72 h, when some changes were detected, the cells were already damaged and highly granular (Figure 6D). This evidence concerns the gene IRF7 and infection.