The observation that G3BP1 binds to RasGAP on the very same sequence that mediates the tumor sensitizing activity of fragment N2 and the fact that G3BP1 is over-expressed in some cancer cells made G3BP1 a good candidate for the TAT-RasGAP317–326 peptide ability to lower the resistance specifically in cancer cells. Here, G3BP1 is linked to neoplasm.