G3BP1 and neoplasm: As G3BP1 binds to amino acid 317–326 of RasGAP, an attractive hypothesis to explain how TAT-RasGAP317–326 sensitizes specifically tumor cells to genotoxin-induced death was that the peptide inhibits the ability of G3BP1 to form stress granule and consequently, as stress granules may exert anti-apoptotic properties [16], decreases the resistance of cancer cells towards apoptosis.