Ambati et al. [51] detected spontaneous CNV in senescent Ccl-2 (MCP-1) KO mice and Ccr-2 KO mice, while Luhmann et al. [30] were unable to detect any spontaneous CNV in similarly aged Ccl-2 KO mice and revealed that the AMD-like features in MCP-1 KO mice described by Ambati et al. might be the result of aging alone. The gene discussed is CCR2; the disease is age-related macular degeneration.