CD4 and Granuloma: It is important to note that peripheral blood CD4+ or CD8+ T cell counts do not necessarily reflect either the number or function of these T cells at the actual sites of coinfection, although the evaluation of skin lymphocytic infiltrate in HIV/leprosy coinfected patients demonstrated the predominant involvement of CD8+ T cells at the site of disease, in granuloma formation, being more frequent than CD4+ T cells [32].