2) Since targeting c-Met and VEGFR2 downstream signaling with a synthetic multiple tyrosine kinase inhibitor, cabozantinib (XL-184), resulted in remarkable resolution of bone and soft tissue metastases in a large number of patients with solid tumors including CRPC patients [20], [21], it would be important to show if these cell signaling pathways might be activated in clinical specimens and in relevant tumor xenograft models. This evidence concerns the gene MET and neoplasm.