To understand the clinical significance of c-Met signaling activation and EMT in the LNCaP-RANKL model and the associated increases in prostate cancer metastases, we defined the c-Met signaling pathway and EMT in a CRPC LTL-313 xenograft model obtained from the Living Tumor Laboratory (livingtumorcentre.com). This evidence concerns the gene TNFSF11 and prostate carcinoma.