NR3C1 and asthma: The impairment of corticosteroid responsiveness observed in severe asthma has been induced by decreased glucocorticoid receptor (GR) α expression, increased decoy GR receptor (GRβ), defected ligand binding for GR, reduced GR nuclear translocation and GR/glucocorticoid response elements (GREs) binding [3] as well as HDAC2 reduction.