Within the group of subjects investigated for CDC, MOG-IgG dependent TCC formation was found in 2/23 (9%) definite NMO, 5/33 (15%) HR-NMO, 8/19 (42%) ADEM, 1/14 (7%) CIS and 1/14 (7%) CTRL (pediatric patient with genetically confirmed citrullinemia with a MOG-IgG serum titer of 1:640). The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.