AQP4 and acute disseminated encephalomyelitis: AQP4-IgG antibodies were absent in two patients with NMO (4%), 21 patients with HR-NMO (40%), 31 CIS patients (97%) and all patients with ADEM and MS as well as all controls (CTRL) including patients with systemic lupus erythematosus (SLE), other neurological diseases (OND) and healthy individuals (Table 1).