Next, we grouped patients with NMO (n = 23), HR-NMO (n = 33), ADEM (n = 19), CIS (n = 14), MS (n = 10) and CTRL (n = 14) based on their ability to initiate MOG-IgG or AQP4-IgG dependent complement activation (TCC AQP4-/MOG-, TCC AQP4+/MOG- or TCC AQP4-/MOG+; Table 3 and additional file 3). This evidence concerns the gene AQP4 and acute disseminated encephalomyelitis.