Considering the synergistic effects of TGFβ and MAPK pathways in tumorigenesis it is logical to try a combinatorial approach in cancer treatments, where simultaneous partial inhibition of the Ras-MAPK and TGFβ pathways, yields synergistic inhibition of TGFβ ligand induced metatstasis, while having minimal impact on other aspects of TGFβ and Ras-MAPK biology. Here, TGFB1 is linked to cancer.