The increased AVP concentration initially found in HAR depression [17] appeared to belong to the defining characteristic of the ANA subcategory [18], and the psychotic features found in HAR as well as in ANA depression appeared to be better conceived to define a distinct subcategory of psychotic depression (PD) than as the phenotype of the severest form of HAR or ANA depression [10]. The gene discussed is AVP; the disease is depressive disorder.