Our own efforts in blocking FGFR3-isoforms in colorectal tumor cells have demonstrated that FGFR3 blockade mediated by dominant-negative mutant constructs or siRNA can be specifically targeted against FGFR3-IIIb or FGFR3-IIIc which have distinctly different biological impact depending on the choice of target [38]. This evidence concerns the gene FGFR3 and colorectal neoplasm.