The effects of MA and MA128 (300 mg/kg) and CsA treatment on leukocyte subsets in lungs and BALF included marked changes in the numbers of CD4+ helper T cells, CD8+ c/s T cells, Gr-1+CD11b+ granulocytes, CCR3+ eosinophils, CD4+CD25+ activated T cells, and B220+CD23+ B cells in a mouse model of asthma compared to control group, and the deficits in CCR3+ eosinophils were accompanied by concurrent decreases in eosinophils in BALF cytospin (Figures 4(d) and 4(e)). The gene discussed is CD8A; the disease is asthma.