Proinflammatory mediators such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, nitric oxide (NO), and prostaglandin E2 (PGE2) play a critical role in the process of disease development in ALI [3]; while NO and PGE2 are generated by inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2, respectively, expression of TNF-α, IL-6, iNOS, and COX-2 are regulated by transcription factor, nuclear factor (NF)-κB, activation [5]. The gene discussed is NOS2; the disease is acute respiratory distress syndrome.