Potential mechanisms for PI-associated dyslipidemia include (a) inhibition of sterol regulatory element-binding protein-1 (SREBP-1) activation in the liver and/or adipocytes along with the protease-mediated breakdown of apolipoprotein-B [23], (b) direct enhancement of the formation of very-low-density lipoproteins (VLDLs) [24] and the reduction of lipoprotein lipase activity [25], and (c) changes in the mobilization of lipid stores [26]. Here, SREBF1 is linked to metabolic syndrome.