NFKB1 and plasma cell myeloma: Data available in the literature show that during carcinogenesis many components of the NF-κB signalling systems are changed or mutated in such a way that the activity of the transcription factor is increased (for example in multiple myeloma, Annunziata et al., 2007; lung cancer, Tang et al., 2006; and colon cancer, Charalambous et al., 2009).