MYC and neoplasm: Yet more surprisingly, given its lack of toxicity in normal proliferating tissues, Myc inhibition has an unexpectedly potent cytotoxic impact on tumor cells, triggering rapid and complete regression of both K-RasG12D-driven non-small cell lung cancer [48] and of SV40 large T/small t antigen-driven pancreatic islet tumors in RIP1-Tag2 mice [49], irrespective of stage of the tumor progression.