MYC and non-small cell lung carcinoma: Of note, out of literally hundreds of individual lung tumors in the KRasG12D-driven NSCLC mouse model, no tumors resistant to Myc inhibition have ever emerged (Soucek & Evan, unpublished data), consistent with the unique, essential non-redundant role that Myc plays: tumor cells cannot circumvent their need for Myc by compensation or evolution.