MYC and neoplasm: A careful kinetic analysis of Myc-inhibition-induced tumor regression in the RIP1-Tag2 model demonstrated that inhibition of endogenous Myc triggers the rapid collapse of the tumor microenvironment, with concomitant apoptosis of endothelial cells, suppression of all detectable interaction between VEGF and its receptor, inhibition of both recruitment and/or retention of the inflammatory cells macrophages and neutrophils, vascular collapse and hypoxia [49, 50].