PFKFB4 and neoplasm: Among the shared ‘hypoxia up' genes we identified genes involved in carbohydrates metabolism, fructose, mannose, and glycolysis, (i.e., SLC2A1, also known as GLUT1, PGM1, ALDOA, ALDOC, PFKFB3, PFKFB4, GYS1, GBE1, HK2, ENO2 and PGK1), genes involved in oxidoreductase activity (i.e., SCD, P4HA2, P4HA1, HMOX1 and EGLN1), in autophagy and tumor cell survival (i.e., BNIP3L) [32], in pH regulation (i.e., CA9) [33] in multidrug resistance (i.e., ABCB6) [34] in cell survival and proliferation (i.e., ADM, cyclin G2), in angiogenesis (i.e., EGLN1, ANG and ANGPTL4).