The interest in HIF-1 comes form the fact that HIF-1 controls the expression of numerous genes involved in many aspects of cancer progression, including angiogenesis (e.g., vascular endothelial growth factor - VEGF), metabolic adaptation (e.g., Glut1), apoptosis resistance (e.g., Bcl2), invasion and metastasis (e.g., c-Met) [6]. The gene discussed is VEGFA; the disease is cancer.