HIPK2 and neoplasm: We also found newly identified HIF-1a target genes such as TMEM45A, ANKRD37 and WSB1 [35], the latter one being involved in ubiquitination and degradation of HIPK2 [36], a putative tumor suppressor and p53 apoptotic regulator [37] that is down-regulated in hypoxia [38], supporting the hypoxia-mimetic function of cobalt.