When co-cultured with human fibroblasts, SACC-LM cells exhibited an enhanced invasion activity, that was 2.21±0.68-fold (SACC-LM cells group), and 1.71±0.54-fold (EMMPRIN-blocked SACC-LM cells group) higher than that when cultured alone (Fig. 4). Here, BSG is linked to lymphangioma.