After the identification of the down-regulation of miR-15/16 promoting anti-apoptosis via up-regulating Bcl-2 expression in leukemias and lymphomas, more miRNAs promoting anti-apoptosis by directly or indirectly regulating Bcl-2 family proteins have been observed in many types of cancer, including breast cancer (32). The gene discussed is BCL2; the disease is breast cancer.