It is also interesting to note the study of Kanno et al, wherein they showed that human leukemia cell lines NALM-6 and HL-60, which have constitutively activated NF-κB signaling (31,32), are sensitive to DDTC treatment while K562 cell line was mostly unaffected by DDTC (22). The gene discussed is NFKB1; the disease is leukemia.