Interestingly, a recent study by Yang et al demonstrated that BRMS1 reduces CXCR4 expression in lung cancer cells via abrogation of NF-κB activation (12); however, the functional implications of BRMS1 and its relationship to the CXCR4 signaling pathway in ovarian neoplasms are not clear. This evidence concerns the gene BRMS1 and ovarian neoplasm.