LPAR1 and breast carcinoma: To analyze the role of LPA1 during the early steps of the metastatic dissemination of breast cancer cells, mice were inoculated orthotopically with 4T1 cells in the mammary gland and treated with Debio 0719 (25 and 50 mg/kg) administered orally per os twice daily, or with the vehicle only, from day 0 to 14 post cell injection.