GDAP1 and Charcot-Marie-Tooth disease: GDAP1 mutations are responsible: for CMT4A [MIM:214400] [2], the most frequent recessive subtype of demyelinating CMT; for AR-CMT2 [MIM:607706] [3], the axonal recessive subtype; for CMTRIA [MIM:608340] [4], the intermediate recessive CMT; and for CMT2K [MIM:607831] [5-7], the rare dominant subtype.