Emerging evidence from increasing number of investigations on isoflavones has shown that isoflavones exert their pleiotropic effects on cancer cells through targeting multiple cellular signaling pathways including NF-κB, Akt, MAPK, Wnt, Notch, p53, and AR pathways, suggesting that isoflavone could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies. The gene discussed is NFKB1; the disease is cancer.