We have reported that isoflavone up-regulated the expression of GSK-3β, enhanced GSK-3β binding to β-catenin, increased the phosphorylation of β-catenin, and induced apoptotic cell death, suggesting that isoflavone could inactivate Wnt signaling to induce apoptosis and inhibit prostate cancer cell growth [94]. The gene discussed is GSK3B; the disease is prostate cancer.