Nam et al. (2010) have shown that loss of Rab25 promotes intestinal neoplasia, and low levels of Rab25 are associated with human colorectal cancer. Rao and coworkers (Cheng et al., 2006, 2010) have found that Rab25 expression is reduced in many breast tumors, and its loss in estrogen-receptor-negative breast cancer cell lines promotes aggression. The gene discussed is RAB25; the disease is colorectal cancer.