Familial CJD (fCJD) is associated with dominantly inherited point mutations in PRNP. There is a region of 5 repeats within PrP from residues 51-91 comprised of a nonapeptide PQGGGGWGQ and four tandem octapeptide repeats (PHGGGWGQ)4. This evidence concerns the gene PRNP and Creutzfeldt Jacob disease.