Even on adjusting individually for the stage, tumor size, grade and margin status of PDAC tumor samples, moderate to high Smad4 protein expression positively influences survival significantly [Log Rank (Mantel-Cox) Chi-Square 8.250, significance .004; Log Rank (Mantel-Cox) Chi-Square 9.772, significance .002; Log Rank (Mantel-Cox) Chi-Square 9.377, significance .002; Log Rank (Mantel-Cox) Chi-Square 8.524, significance .004]. Here, SMAD4 is linked to neoplasm.