VEGFA and breast cancer: Previously, MTDH has been shown to induce the lung metastasis with a “lung-homing domain” selected from lung-homing Balb/c-derived 4T1 mammary tumor cell line phage cDNA library and has been related to tumor angiogenesis with the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) [16], [17].