In addition, it has been demonstrated that specific LRP6 antibodies were able to block MMTV-Wnt1 or MMTV-Wnt3 xenografts in vivo[17], [18], and that recombinant Mesd protein, an LRP6 antagonist, markedly suppressed tumor growth in MMTV-Wnt1 xenograft models [15]. This evidence concerns the gene WNT1 and neoplasm.