Finally, we studied expression of alternative mRNA isoforms (derived from NDUFV3, ZNF121, PDE4D, and WEE1) in prostate biopsies from patients with PCa (Figure S3C), and found that although alternative exons were expressed in clinical PCa, there was no association with disease progression (p>0.05). This evidence concerns the gene WEE1 and posterior cortical atrophy.