The ability of the IFN-α to induce anti-proliferative and anti-tumor progression responses [24], [47] made it an interesting candidate to study in relation to CysLT2R. IFNs have been reported to mediate their anti-tumor effects by altering immune responses, such as the suppression of cytokine IL-1 [48] and inducing TRAIL [49], and by inducing anti-angiogenic responses by inhibiting VEGF [50]. This evidence concerns the gene CYSLTR2 and neoplasm.