For example, there are reports showing an increased prevalence of anti-Sm and anti-RNP antibodies in African patients relative to Europeans [16], [17], [18], [19]; other differences concern clusters of autoantibodies that include anti-Sm or anti-dsDNA [20], or other specific SLE autoantibodies like anti-P [21] or anti-RNA helicase A [18], [22]. Here, RNPC3 is linked to systemic lupus erythematosus.