CD4 and Dravet syndrome: To evaluate the paradoxal effect of DS in CD4-DNTGFβRII mice, which showed lower T conjunctival cell infiltration after DS, we used a co-culture system where CD4+ T cells isolated from spleens and cervical lymph nodes of WT and CD4-DNTGFβRII mice were used as responders and cornea and conjunctiva explants obtained from NS and DS5 mice as stimulators [29].