After adjusting for age, sex, hypertension, BMI, TC, TG, hyperinsulinemia, hs-CRP, IgE, tryptase, and chymase, only hs-CRP (OR: 3.814 [1.588–9.162, 95% CI], P = 0.003) and IgE (OR: 3.367 [1.379–8.197, 95% CI], P = 0.008) remained significant risk factors for pre-diabetes, whereas hypertension, WHR, BMI, TC, HOMA-β, HOMA-IR, hs-CRP, and IgE became significant risk factors for diabetes mellitus (Table S1). The gene discussed is IGHE; the disease is hyperinsulinism.