Except age and sex, all tested variables (hypertension, WC, WHR, BMI, TC, TG, low HDL, high LDL, hyperinsulinemia, HOMA-β, HOMA-IR, IgE, tryptase, and chymase) were significant risk factors for pre-diabetes, when interacting with high plasma hs-CRP levels before or after adjustment (Table S2). The gene discussed is IGHE; the disease is Hyperinsulinemia.