These observations suggest that high plasma hs-CRP, in combination with high plasma IgE, increased the risk of developing pre-diabetes and diabetes mellitus with an odds ratio (OR) of 2.204 (1.020–4.759, 95% CI) before adjustment and an OR of 2.251 (1.037–4.885, 95% CI) after adjustment. The gene discussed is IGHE; the disease is diabetes mellitus.