When we performed binary logistic regression analysis, we found that interactions of high IgE with hypertension, WC, WHR, TC, low HDL, high LDL, hyperinsulinemia, HOMA-β, HOMA-IR, and chymase significantly increased the risk of having pre-diabetes before and after adjustment, compared with those from the NGG (Table S3). The gene discussed is IGHE; the disease is Hyperinsulinemia.