IGHE and diabetes mellitus: Interactions of chymase and IgE, however, greatly increased the OR before adjustment (OR: 2.479 [1.079–5.778, 95% CI], P = 0.033) and after adjustment (OR: 2.594 [1.118–6.018, 95% CI], P = 0.026) for all common diabetes mellitus risk factors (Table 4), suggesting a dependent contribution of plasma chymase and IgE to pre-diabetes and diabetes mellitus.