For example, IgE levels impact the risk of pre-diabetes and diabetes mellitus (OR: 1.674 [1.039–2.698, 95% CI], P = 0.034), but chymase alone did not affect the risk of pre-diabetes and diabetes mellitus significantly (OR: 1.387 [0.858–2.244, 95% CI], P = 0.182) (Table 2). The gene discussed is IGHE; the disease is diabetes mellitus.