CD8A and systemic lupus erythematosus: Similarly, autoantigen-specific CD8+ Tregs including CD8+CD28− cells have been reported to be induced in vitro via stimulation of peripheral T cells obtained from patients with systemic lupus erythematosus (SLE) in the presence of a combination of common gamma chain (γc) cytokines IL-2, IL-7 and IL-15 [21].