In addition, in a classical mouse model of food allergy using C57BL/6, Arias et al showed that a PAF-antagonist, but not a histamine antagonist inhibited systemic PE anaphylaxis [9].Recently in the same model, very high amounts (3.75 mg) of peanut injected intravenously induced anaphylaxis in mast cell deficient mice, which was dependent on macrophages and to lesser extent on basophils [26]. This evidence concerns the gene PCLAF and food allergy.